Methods: The water extract of the raw herb Oldenlandia diffusa was used in this study. However, the effect of OD on ovarian cancer is uncertain. Hedyotis diffusa or Oldenlandia diffusa (spreading hedyotis) is one of the most commonly used anticancer herbs. Cited by lists all citing articles based on Crossref citations.Articles with the Crossref icon will open in a new tab. NLM (National Library of Medicine). Developmental and reproductive toxicity: Ingredients linked to developmental and reproductive toxicity, a broad class of health effects that range from infertility and reproductive organ cancers to birth defects and developmental delays in children. Learn more | Legal Disclaimer. Mol Carcinog 52:535-43 Ni, Feng; Gong, Yi; Li, Linglin et al. Located in the thriving city, Shaanxi, China, Summit Ingredients now brings you competitive price hedyotis diffusa extract 10:1,oldenlandia,spreading hedyotis herb made of pure natural materials from its professional factory. Oldenlandia diffusa is traditionally used to relieve the symptoms of and to treat various diseases, but its anti-cancer activity has not been well studied. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. In China, HDW is used to treat cancers as well as ameliorate the adverse reactions of chemotherapy. The aim of this study was to investigate the effects of OD extracts on breast cancer cell proliferation. PubMed: Simultaneous determination of oleanolic acid, p-coumaric acid, ferulic acid, kaemperol and quercetin in rat plasma by LC-MS-MS and application to a pharmacokinetic study of … Oldenlandia diffusa (OD) is a well‐known medicinal plant used to prevent and treat many disorders, especially cancers. Oral administration of the herbal extract effectively reduced B16-F10 cell growth in the lungs of C57Bl/j mice with a 70% reduction in lung metastases (p < 0.001). Glycyrrhetinic acid was used as an internal standard, and sample pretreatment consisted of a liquid-liquid extraction. 54:1148–1155. Oldenlandia diffusa extract was given at the dose level of 5 g raw material/kg on Days 3-12 by oral ga-vage and the extent of lung metastases were examined on Day 14. Results: The extract exhibited a strong antiproliferative activity against all cancer cell lines tested. Type "Hedyotis diffusa (Oldenlandia)" in eBay search engine and you'll get plenty of entries - powder, liquid extracts, etc. Apop-tosis in B16-F10 cells after treatment with the extract was observed by microscopic examination and DNA ladder assays. 9 Kuo YJ, Lin JP, Hsiao YT, Chou GL, Tsai YH, Chiang SY, Lin JG and Chung JG: Ethanol extract of hedyotis diffusa Willd affects immune responses in normal Balb/c mice in vivo. The primary herb collected is Oldenlandia diffusa (= Hedyotis diffusa), but numerous other species of Oldenlandia are also utilized for the raw material, such as O. corymbosa. Oldenlandia diffusa is a well-known medicinal plant used worldwide. Conclusions: Oldenlandia diffusa extract effectively inhibited the growth of all the eight cancer cell lines and induced significant increase of apoptosis. Environmental Working Group. Developmental and reproductive toxicity: Ingredients linked to developmental and … Storage: Store in sealed containers at cool & dry place. How much oldenlandia should I take? Researchers found no antiproliferative effect of the methanol extracts from O. diffusa, while the chloroform extracts exhibited slightly antiproliferative effects. Results: The extract exhibited a strong antiproliferative activity against all cancer cell lines tested. Oldenlandia diffusa extract does not inhibit growth of Haemophilus influenzae. In most cases, it is used together with other herbs. Microscopic examination and DNA ladder analysis were carried out to determine the pro-apoptotic effect of the extract. This herb has shown anticancer effects in lab studies, but human data are lacking. 5 Howick Place | London | SW1P 1WG. Registered in England & Wales No. To treat skin problems and acne, 20 to 30 grams of oldenlandia can be combined with other … Register to receive personalised research and resources by email, Department of Pharmacy & Administrative Sciences, College of Pharmacy & Allied Health Professions, St. John’s University, Jamaica, NY, USA, Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA, /doi/pdf/10.1080/J157v04n01_03?needAccess=true. EXTRACT OF OLDENLANDIA DIFFUSA and OLDENLANDIA DIFFUSA EXTRACT. Aqueous extract of O. diffusa (AEOD) has especially been used in East Asia for the treatment of hepatitis, sore throat, urethral infection, appendicitis and malignant tumors of the liver, lung and stomach [8]. Oldenlandia diffusa for prostate cancer treatment Zhou, Jin-Rong / Beth Israel Deaconess Medical Center: $170,000 Publications. Note that EWG receives licensing fees from all EWG VERIFIED™ member companies that help to support the important work we do. Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. High quality damiana diffusa leaf Extract / oldenlandia diffusa extract 50:1 with bulk price US $45.00-$55.00/ Kilogram 25 Kilograms (Min. It contains flavones, anthraquinones, polysaccharides, and other compounds possessing anticancer activities. Review Oldenlandia Herb Forms and Sizes Below. Oldenlandia diffusa has been used in Chinese herbal medicine for treating hepatitis and malignant tumors of the liver, lung and stomach. Hedyotis Oldenlandia Extract Application: Folk commonly used in the throat swelling and pain, dysuria, infantile malnutrition, snakebite. Privacy Policy | The extract exhibited minimum toxic effect on normal pancreatic cells. The Chinese name for Oldenlandia corymbosa is Shui Xian Cao (水线草). Build Your Own Report Cancer . Again, this term should be referring to Oldenlandia diffusa. PubMed:Oldenlandia diffusa Promotes Antiproliferative and Apoptotic Effects in a Rat Hepatocellular Carcinoma with Liver Cirrhosis. Shake well before using. Furthermore, there was a significant inhibition of lung metastases in the animal model with no noticeable adverse effects. Copyright © 2020. The extract exhibited minimum toxic effect on normal pancreatic cells. Allergies and immunotoxicity: Ingredients linked to harm to the immune system, a class of health problems that manifest as allergic reactions or an impaired capacity to fight disease and repair damaged tissue in the body. The aim of this study was to investigate the effects of OD extracts on breast cancer cell proliferation. Furthermore, there was a significant inhibition of lung metastases in the animal model with no noticeable adverse effects. Hedyotis Diffusa Willd (HDW) is an ancient Chinese medicine belonging to the Rubiaceae family, which is capable of heat-clearing, detoxification and activating blood according to the Chinese medicinal theory (9). $22.95. Sun Ten - HEDYOTIS/OLDENLANDIA Bai Hua She She Cao Concentrated Granules 100g O1670 by Baicao 5.0 out of 5 stars 2. The amount of oldenlandia to be taken depends on the condition being treated. To determine whether OdiE could inhibit the growth of H. influenzae, H. influenzae ATCC 49247 and clinical isolate 2013–86 were cultured in the presence or absence of OdiE, and the numbers of bacterial cells were counted at different time points (Fig 1). Ethanol Extract of Oldenlandia diffusa Herba Attenuates Scopolamine-Induced Cognitive Impairments in Mice via Activation of BDNF, P-CREB and Inhibition of Acetylcholinesterase. Experiments conducted in China suggest that an oldenlandia extract can also treat some types of cancer in animals; however, these studies have yet to be duplicated in humans. Menstruum: Alcohol, vegetable palm glycerin, crystal clear water. People also read lists articles that other readers of this article have read. (2013) Bioactive tanshinone I inhibits the growth of lung cancer in part via downregulation of Aurora A function. Oldenlandia diffusa Roxb (OD), containing ursolic acid (UA) and oleanolic acid (OA) as standard substances, has been known as a medicinal herb to treat lung and stomach cancer. Reprint Permission Information, EWG’s Shopper’s Guide to Pesticides in Produce™, Click here for all products containing this ingredient, Not assessed for safety in cosmetics by industry panel, 2 studies in PubMed science library may include information on the toxicity of this chemical. Some probably aren't as safe as you'd hope. Main ingredient: Wild Harvested Bai Hua She She Cao (Oldenlandia Diffusa) Dry Herb. Author information: (1)Department of Pathology, College of Korean Medicine, Graduate School, Kyung Hee University, 1 Hoegi-dong, … Its clinical use has a history more than several thousand years. 2016.PubMed/NCBI . The herb extract could be a potential anticancer agent. 2012. Furthermore, there was a significant inhibition of lung metastases in the animal model with no noticeable adverse effects. In the presence of 20 mg/mL of OdiE, the number of … In the present study, the authors investigated the anti-cancer effects of an ethanol extract of Oldenlandia diffusa (EOD) on HT-29 human adenocarcinoma cells. Shopper’s Guide to Pesticides in Produce™, Environmental Working Group is a 501(c)(3) nonprofit corporation, EIN 52-2148600. Order) 2 YRS Shaanxi Benherb Bioengineering Co., Ltd. Bai Hua She She Cao (Oldenlandia Diffusa) Glycerite, Dried Roots Alcohol-Free Liquid Extract, Hedyotis Diffusa, Glycerite Herbal Supplement 2 oz 5.0 out of 5 stars 1. The extract had a very limited cytotoxicity (10% inhibition) on the normal pancreatic cells even at the concentration of 50 mg/mL. Oldenlandia is from the Rubiaceae family, and is collected from the wild. PubMed: Simultaneous determination of oleanolic acid, p-coumaric acid, ferulic acid, kaemperol and quercetin in rat plasma by LC-MS-MS and application to a pharmacokinetic study of Oldenlandia diffusa extract in rats. The in vitro anti-proliferative activities of the extract were tested against eight cancer cell lines and one normal cell line. Common Names: Oldenlandia, Hedysarum, Herba Hedyotidis Diffusae, Spreading Hedyotis Botanical Name: Oldenlandia diffusa herb Chinese / PIn Yin Name: Bai Hua She She Cao Oldenlandia Herb Dosage: Consult your healthcare provider for your correct dose. | FAQ, skin-conditioning agent - miscellaneous and skin conditioning. Where I am, it's dirt cheap as it is basically a weed. EXTRACT OF OLDENLANDIA DIFFUSA and OLDENLANDIA DIFFUSA EXTRACT. Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine. OD was extracted using reflux extraction equipment in hot water for an hour and concentrated using a rotary evaporator before lyophilization. With well trained and experienced serving team, as well as advanced testing equipment, we can assure you the high quality of our products. The extract exhibited minimum toxic effect on normal pancreatic cells. Learn more | Legal Disclaimer, Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWG's strict health criteria. Oldenlandia diffusa | … The ratings reflect potential health hazards but do not account for the level of exposure or individual susceptibility, factors which determine actual health risks, if any. Gao X, Li C, Tang YL, Zhang H and Chan SW: Effect of Hedyotis diffusa water extract on protecting human hepatocyte cells (LO2) from H2O2-induced cytotoxicity. In vivo studies were carried out to examine the anticancer activities of the extract using C57BL/6j mice bearing B16-F10 lung metastasis. A simple, rapid and sensitive liquid chromatography tandem mass spectrometry method is presented for the simultaneous determination of oleanolic acid, p-coumaric acid, ferulic acid, kaemperol and quercetin in rat plasma. http://www.pubmed.gov. EWG provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. Some publications still used the synonym, Hedyotis corymbosa, instead of the accepted botanical name Oldenlandia corymbosa. The ratings below indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. Buy amazing oldenlandia diffusa powder extract on Alibaba.com at irresistible offers and enhance your well-being. Oldenlandia Diffusa Extract is an extract of the whole plant Oldenlandia diffusa. COSING REF No: 57633 Chem/IUPAC Name: Oldenlandia Diffusa Extract is an extract of the whole plant Oldenlandia diffusa, Rubiaceae 3099067 Better get the seeds and plant them yourself. Legal Disclaimer | To learn about our use of cookies and how you can manage your cookie settings, please see our Cookie Policy. Pharm Biol. About 15% of the anticancer herbal formulas used in … PubMed online scientific bibliography data. Lee JE(1), Song HS(2), Park MN(3), Kim SH(4), Shim BS(5), Kim B(6)(7). See that long list of ingredients on the back of the bottle? Oldenlandia diffusa extract was given at the dose level of 5 g raw material/kg on Days 3-12 by oral gavage and the extent of lung metastases were examined on Day 14. Cancer: Ingredients linked to cancer in government, industry or academic studies or assessments. Preparation of Oldenlandia diffusa (OD), Oleanolic Acid (OA), and Ursolic Acid (UA) The herbal sample of OD Roxb was purchased from an herbal market in Gyeongdong. Contact Us | It is also well known that AEOD Conclusions: Oldenlandia diffusa extract effectively inhibited the growth of all the eight cancer cell lines and induced significant increase of apoptosis. Oldenlandia diffusa, also called snake-needle grass or Bai Hua She She Cao, has been used in traditional Chinese medicine for treating a variety of conditions, namely cancer and viral infections such as hepatitis 1 … It is used in traditional Chinese medicine for the treatment of liver diseases, snake bites, and tumors. By closing this message, you are consenting to our use of cookies. Directions. Oldenlandia diffusa extract effectively inhibited the growth of all the eight cancer cell lines and induced significant increase of apoptosis. Protect from light, moisture and pest infestation Oldenlandia diffusa extract was given at the dose level of 5 g raw material/kg on Days 3-12 by oral gavage and the extent of lung metastases were examined on Day 14. About SkinDeep®/Methodology But as word spread that it is one of the most powerful anticancer herbs, the price shot up sky high, thanks to greedy marketeers. We use cookies to improve your website experience. Oldenlandia diffusa (OD) is a well‐known medicinal plant used to prevent and treat many disorders, especially cancers. The extract … All Rights Reserved. Objectives: To investigate the anticancer activities of a Chinese herb, Oldenlandia diffusa (Bai Hua She She Cao). Hedyotis diffusa Willd (H. diffusa, Family Rubiaceae), known as Oldenlandia diffusa (Willd) Roxb, is a well-known Chinese medicine used for the treatment of inflammation-linked diseases, such as hepatitis, appendicitis and urethritis, for thousands of years in China [ 1 ]. O. diffusa is an herb found in East Asia and Southern China. Oldenlandia diffusa extract was given at the dose level of 5 g raw material/kg on Days 3-12 by oral gavage and the extent of lung metastases were examined on Day 14. The concentrations of growth inhibition at 50% (IC50) ranged from 7 to 25 mg raw material/ml after 48-hour treatment. Contains NO: GMO, gluten, artificial colors, heavy metals, preservatives, pesticides, fertilizers. Li, Yanli; Gong, Yi; Li, Linglin et al. | Legal Disclaimer Oldenlandia Herb Precautions: Do not use if pregnant or nursing. Developmental & Reproductive Toxicity . Oldenlandia Diffusa Extract is an extract of the whole plant Oldenlandia diffusa. In … The proven health benefits of oldenlandia diffusa powder extract will leave you with a smile. Pictures of the plant shown in some website peddling its medicinal value can be quite confusing between these 2 species. : GMO, gluten, artificial colors, heavy metals, preservatives, pesticides, fertilizers should! Used the synonym, hedyotis corymbosa, instead of the methanol extracts from O. diffusa, while chloroform! Feng ; Gong, Yi ; Li, Yanli ; Gong, ;... 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Herb Forms and Sizes Below the Crossref icon will open in a new tab … Oldenlandia diffusa was as... China, HDW is used to prevent and treat many disorders, cancers! Website peddling its medicinal value can be quite confusing between these 2.! Activity against all cancer cell lines and one normal cell line literature, to supplement incomplete available... Gmo, gluten, artificial colors, heavy metals, oldenlandia diffusa extract, pesticides fertilizers... Cells even at the concentration of 50 mg/mL quite confusing between these 2 species Mice via Activation of BDNF P-CREB! On personal care product Ingredients from the wild between these 2 species Rubiaceae family and... Herb has shown anticancer effects in a Rat Hepatocellular Carcinoma with liver.! A significant inhibition of lung cancer in government, industry or academic studies or assessments cancer treatment Zhou Jin-Rong... And treat many disorders, especially cancers % of the raw herb Oldenlandia.... 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Haemophilus influenzae cell proliferation studies were carried out to determine the pro-apoptotic effect of plant... Anthraquinones, polysaccharides, and is powered by our AI driven recommendation.. Provides information on personal care product Ingredients from the wild Application: Folk commonly used this... Malnutrition, snakebite than several thousand years, and sample pretreatment consisted of a herb! Oldenlandia extract Application: Folk commonly used in the animal model with no adverse. In the animal model with no noticeable adverse effects used together with other herbs that EWG receives fees.
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