The researchers put it well in the discussion portion: “Choline is an essential nutrient; therefore, it must be consumed in the diet for optimal health. When it comes to choosing between CDP-Choline or Alpha GPC for your nootropic stack. Alpha GPC is a byproduct of phosphatidylcholine, Alpha GPC was able to increase cognitive function, Piracetam, Aniracetam, Oxiracetam, Pramiracetam, and Noopept, Antal A, Kéri S, Bodis-Wollner I. L-alpha-glycerylphosphorylcholine enhances the amplitude of the pattern electroretinogram in rhesus monkeys. What this means to you: AGPC would be better taken before bed or rest, and should not really be taken before training or exercise, since it will have (mildly) counterproductive effects on exercise intensity, but could help you ‘rest and digest’ better. Choline supplements (particularly alpha GPC) are able to penetrate this barrier and then they can be made into acetylcholine once they are inside the brain. The Cortex nootropic stack: https://www.livecortex.com/cortex-generation1-nootropic/ The Cortex nootropics and biohacking blog: https://www.livecortex.com/blog I’d go with CDP Choline / Citicoline any day over GPC. If one worked better, then you know the correct choice for you. Some individuals find that Alpha GPC is faster acting and produces more noticeable effects while others make the same claims about CDP Choline. The reason is the lower choline content in the molecule, which is about 18.5%. Eur J Drug Metab Pharmacokinet. Other names: Choline alphoscerate / L-Alpha glycerylphosphorylcholine. Since the acetylcholine molecule won’t penetrate this barrier, you wouldn’t be able to increase its levels in the brain directly, which means it wouldn’t be able to bind to cholinergic receptors on your neurons. Alpha-GPC is a ‘step closer’ to acetylcholine than CDP-Choline, whereas CDP-Choline is more closely associated with phosphatidylcholine synthesis. A 10% voucher has been generated for you. It seems logical to begin with the ‘alpha’ i.e. Citicoline vs Alpha GPC. If you are interested in the many benefits provided by CDP-Citicoline, by all means, go for it. Alpha GPC vs CDP Choline - posted in Brain Health: Which one should I get (using piracetam for help with memory, as ive got exams coming up)Also, could someone recommend where to get them (taht ships to UK) I cant use biosynergy Out of the essential nutrients required to keep the brain and the body healthy, choline is considered a vital one. Alpha GPC is a byproduct of phosphatidylcholine and is … There really is no contest. What this means to you: In contrast to AGPC which activates the PARAsympathetic nervous system (‘rest and digest’), CDP choline has the opposite effect in that it activates the sympathetic nervous system and therefore ‘amps you up’ (so to speak) to a modest degree. We'll also send you a 10% discount to use on your next order! Able to provide high levels of choline (better than citicoline/CDP choline) to neurons as well as protecting their cell walls. Until further clinical research is completed, it is very hard to confidently say which of the two supplements is best. Alpha GPC raises dopamine concentrations in certain regions of the brain and citicoline affects the release of dopamine and densities of dopamine receptors. While early research points to Alpha GPC being more potent, these results are still inconclusive. This is a big reason for us including CDP Choline in Neurodrive. Currently there have only been two studies done comparing the two options (injected intramuscularly). But in a straight-up fight between CDP Choline and Alpha GPC, you have to look at bioavailability. Both supplements are shown to be effective ‘anti-aging’ agents for the nervous system.? There is an science article out reviewing GPC and free range choline and it’s increase in lethal prostate cancer and it is all bad news for GPC first then free change choline. A-GPC vs. CDP Choline. Our bodies turn choline into CDP Choline, or cytidine diphosphate-choline. On the other hand, Alpha GPC is a byproduct of phosphatidylcholine instead of a precursor. What this means to you: Um, not much really… unless you want to ‘out geek’ your mates. Taking alpha GPC could lead to improved vitality and increased strength as it helps muscles recover after exercise. The first study showed that Alpha GPC was able to increase cognitive function more than CDP choline, and the second showed that Alpha GPC also resulted in higher plasma levels of choline. Mech Ageing Dev. By NOT messing around with dopamine levels, but instead, becoming slightly more sensitive to your own normal dopamine levels (by increasing the number of receptors and therefore being more ‘sensitive’ to that neurotransmitter), we create a win-win scenario. Thanks for linking the article, very informative. Bitartrate is a precursor to acetylcholine. Until more studies are done comparing the two, it is hard to say which is better per se, and it often just comes down to personal preference. While Alpha GPC seems to be the clear winner , it’s proposed that the method of ingestion may have had an impact and also that the plasma levels may indicate higher uptake of CDP choline. Citicoline (CDP Choline) Citicoline (or CDP Choline) is more than a choline source. CDP choline does not have this problem.. So we get more ‘drive’ and ‘zing’, but without the crash or the addiction. Some users state that they find Alpha-GPC to act faster than CDP choline in … You should always check that your Alpha GPC container is tightly closed against possible moiosture ingress and that the little bag of dessicant is still inside the container. Free UK Shipping on orders over £35 & £200 Globally. – In other words, this particular choline source activates the ‘rest and digest’ pathways and de-activates (to a degree) the ‘fight or flight’ pathways. Both of these options are highly effective when stacked, especially with racetams which create a higher demand for Acetylcholine. 3. For one, alpha-GPC raises choline blood levels to a greater extent than CDP-choline. I heard a good alternative to alpha gpc and cdp is a choline bitartrate/ alcar combo but that is if you are low on fund. Both Citicoline and alpha gpc giving the two ingredients their own distinct nootropic benefits.. This is the filtration system that separates your circulating blood flow from brain tissue. CDP-choline and Piracetam. Okay, the articles helped. 3. Piracetam is a powerful nootropic that needs to be paired with an external choline source. This offers enhanced cognitive functionality, and it also targets anxiety and depression. Both have the same recommended dosage of 100 – 500 milligrams per day, but Alpha GPC costs about $53, whereas CDP choline goes for about $40 on average. 1. Try them both out. Good question! Alpha GPC vs CDP Choline: What’s the difference? ALCAR vs Alpha GPC vs CDPCholine - posted in Brain Health: What's the difference? CDP Choline has been shown to prevent damage to dopaminergic neurons and MAY (though not conclusive) increase dopamine receptor density. The synthesis of acetylcholine (ACh) is largely dependent on the choline provided by phosphatidylcholine (PC). ATA Mg® Magnesium N-Acetyltaurinate Capsules, Lion's Mane Mushroom 8:1 Dual Extract Capsules, Red Reishi Mushroom 16:1 Extract Capsules, Rhodiola Crenulata Extract | 3% Salidroside, ATA Mg® Magnesium N-Acetyltaurinate Powder, Panax Ginseng Leaf Powder (20% Ginsenosides), Panax Ginseng Root Powder (20% Ginsenosides). What this means to you: Lets be honest, this bit of information is of limited practical use. 5. 1991, Scapicchio PL. Low concentrations of choline are associated with the development of fatty liver and liver damage (34, 35). Arch Gerontol Geriatr. CDP Choline (Citicoline) Citicoline (CDP-Choline) compound. You can even do a little test of your own. Alpha GPC vs. CDP Choline Cost Alpha GPC is about 13% more expensive per 50 milligrams than DPC choline. Your email address will not be published. A 1,000-milligram dose of a-GPC is equivalent to about 400 milligrams of dietary choline. Betaine intake was not associated with risk of lethal prostate cancer. Since both Alpha GPC and CDP Choline are part of the same process, it is reasonable to ask which is then better for brain health? 2014, Bronzetti E, Felici L, Zaccheo D, Amenta F. Age-related anatomical changes in the rat hippocampus: retardation by choline alfoscerate treatment. Alpha GPC is well tolerated (minimal negative reactions, etc) and has been shown in studies to have a therapeutic role in human patients with acute stroke or TIA (AKA ‘mini stroke’/transient ischemic attack). Acetylcholine is essential for memory formation, learning, and mental attention. If you are already supplementing with PC, then great, the use of CDP choline can only add to that. Acetylcholine cannot be supplemented orally because it cannot cross the blood-brain barrier. Alpha GPC and CDP Choline have both been shown to help cognitive decline, though the former may be more effective; Differences between GPC and CDP. Of course, GH releasers aren’t just for old folks—alpha GPC 29 and probably also CDP-choline 33 stimulate GH release in younger subjects as well. So this mini-article is simply here to help provide a little background information on the essential (and non-essential) differences between two ‘alphabet soup’ choline boosters; Alpha GPC and CDP choline. However, what is unclear to me is, if both CDP Choline, Cognizin or Alpha GPC lead to or aid in the production of Acetylcholine, why not just take Acetylcholine and cut to the chase? Alpha-GPC seems to be more efficient (by weight) than CDP-Choline, and faster acting in terms of increasing brain choline levels. If I’m ever in need of choline, my go-to is either CDP choline or alpha GPC and there isn’t much reason to use soy lecithin (as a source of phosphatidylcholine). There is no easy or known way to mimic the effects of these drugs by merely eating the right diet. Acetylcholine is an organic molecule that acts as a neurotransmitter in the autonomic nervous system. 2013, Choline source to support memory function, Increases levels of acetylcholine neurotransmitter, Promotes brain cell health & communication. J Surg Res. Well, OK, to the neuroscientist there are subtle differences, but you get the point. Taking Alpha GPC or CDP Choline with other nootropics can intensify positive results, but it can also curb some of the possible negative side effects. As alpha GPC breaks down, acetylcholine is released as a byproduct. Prices also tend to vary according to the name (and some overall review ratings). Both of these supplements have long and complex names, and as a result, tend to get shortened to ‘alphabet soup’.? I think the take aways from this article are: Acetylcholine is unable to cross the protective membrane separating the bloodstream from the brain (the blood-brain barrier) so supplementing directly with Acetylcholine does nothing to raise levels in the brain. In turn, CDP-choline has a broader range of potential benefits, but alpha-GPC may have an edge in boosting physical and mental performance [16, 17]. As of now, this question is not easy to answer, and is still a very hot topic for debate. Choline specificialy acts as prescursor to acetylcholine whereas alpha GPC and citicoline both affect dopamine. Although both increase the abundance of Acetylcholine within the body, the metabolism process of each substance is very different. 1999, Amenta F, Del Valle M, Vega JA, Zaccheo D. Age-related structural changes in the rat cerebellar cortex: effect of choline alfoscerate treatment. When stacking either of the two choices you will notice amplified nootropic effects. Your subscription could not be saved. Some of the recommended racetams to stack these supplements with are: Piracetam, Aniracetam, Oxiracetam, Pramiracetam, and Noopept. We can experience the same sort of beneficial effects of increased dopamine, but without the associated negatives. I don’t have access to that article – but it would be interesting to see if they also make any distinction between types of choline and increased risk. What this means to you: AGPC doesn’t need to be capped to avoid a bitter taste. Alpha GPC is more of a post workout or ‘chillout’ type of choline replenishment agent, whereas CDP choline is more stimulatory, making it better for focus and drive.? In the first study, Alpha GPC seemed to increase cognitive function more than CDP choline and in the second, Alpha GPC resulted in higher plasma levels of choline. Royal Mail European services temporarily suspended. 2. This article will cover the different options for choline sources and will compare Alpha GPC vs CDP Choline. Sometimes it’s called Cognizine Citicoline or Citicoline Xognizine, and sometimes simply Citilouine or CDP Choline and probably something else. While there are similarities between cdp choline vs alpha gpc, there are certain differences between them. Both of these supplements are used in the nootropic community and seem to have equally positive reviews. 2. The problem with these studies is that many people propose that the method of ingestion may have had an impact on the data collected. alpha GPC, so here we go: 1. Would ALCAR be a better choice than either of these, as it is a direct source of the neurotransmitter? This choline booster is a derivative of phosphatidylcholine, is sweet tasting and hydroscopic (draws moisture out of the air). ... in mind that to get equal quantities of choline you need slightly more than twice the dosage of citicoline as you do alpha GPC. Please try again. Int J Neurosci. I was pretty concerned when first reading some of its findings, as I have been looking to increase acetylcholine levels via acetyl-L-carnitine and choline supplementation. In multivariate analyses, men in the highest quintile of choline intake had a 70% increased risk of lethal prostate cancer. CDP choline may have a mild, positive effect on dopaminergic neurons. Both are much better than choline bitartrate or citrate ate increasing acetylcholine. What this means to you: Dopamine is hugely important in terms of motivation, desire, pleasure, satisfaction and ‘zest’ for life, etc. But which of these sources is the best has been an issue of much debate recently. Try one out and if it doesn’t really do it for you, switch over to the other. Otherwise known as Citicoline / Cytidine diphosphate sodium choline (CDP-Choline) sodium. What this means to you: Not much, unless you have a relative or friend with alzheimers disease. Unlike, CDP Choline and alpha-GPC, the bitartrate form doesn’t easily cross the blood-brain barrier. This makes CDP choline a better choice for use as a pre-workout or ‘drive’ type choline source. CDP-choline or citicoline is made of choline (with two phosphate groups) and cytidine, while alpha-GPC is made of choline (with one phosphate group) and glycerol. Citicoline, on the other hand, may have other benefits that alpha GPC does not. Excellent tolerability – 44/2044 (2.4%), proven therapeutic role in pts with acute stroke or TIA. Revisiting choline alphoscerate profile: a new, perspective, role in dementia? Most users report positive results when they stack Uridine with Alpha GPC and Piracetam. The obvious difference is that Alpha GPC is 40% choline by weight compared to CDP’s 18-19%; BUT CDP Choline makes up for it by also being a uridine supplement and not just a choline one; Alpha GPC has been proven to enhance the release of Growth … or obviously diagnosed with prostate cancer. When looking at the two supplements individually, it’s quite clear that both have been proven to be effective. This does not point to causation by any means. 4. CDP Choline. As a nootropic choline source, alpha-GPC is spot-on. The pure choline content of the alpha GPC molecule is about 40%. Cdp choline is is good for mental activities, alpha gpc is good for physical activities Both work as a choline source, try out cdp next time and see what you like better level 1 A pilot study. Despite this distinction, the researchers cite a Swedish study in the discussion portion that does point to increased risk of prostate cancer, so there’s that. However, there is still a chance you could have an adverse reaction to Alpha GPC. Alpha GPC does not produce things in exactly the same way as CDP-Choline (Citicoline), or DMAE. Both supplements are generally very well tolerated and side-effect free.? Your email address will not be published. There are several ‘street drugs’ and nutritional supplements (geranamine) that increase dopamine acutely, but these all cause a significant ‘crash’ (not to mention addiction potential, etc). What this means to you: Lets be … Shows PARAsympathetic NS activation and an increase in GABA, which suggests a decrease in nor-adrenergic system activity. 1. What I don’t understand is of Citicoline and Cognizin are the same thing, or (even ever so slightly) different. 1) Caution should be taken with choline supplementation if you are a male with a higher risk of prostate cancer (age, family hx, etc.) 5. Less effectively elevates choline levels compared to Alpha GPC, although with similar efficacy it gets into the brain. Both CDP-choline (28) and alpha GPC 29 improve the age-related decline in GH responsiveness to GHRH, a result which has important implications for cognitive enhancement as well as for muscle building. CDP-Citicoline is probably the most expensive choline source, so if you just want a straight(but highly effective) choline source go with Alpha-GPC. If you prefer to take Citicoline, you may want to stack it with Piracetam, Noopept or Oxiracetam. Although they work differently, both achieve similar results, and are both are much better than other choline sources on the market today. Or if you’d like to cover all the bases, you can use both of them in the same time. During the breakdown of Alpha GPC, the neurotransmitter acetylcholine is produced as a by-product. Often, the full name of supplements gets compressed into acronyms and this can get confusing (for example N-acetyl-L-Tyrosine becomes NALT, dimethylaminoethanol becomes DMAE, etc), especially when dealing with 2 supplements that have (at least, in the mind of the consumer) such similar functions or effects. 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