In: Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine. 2022; doi:10.1016/j.autrev.2022.103037. Objective: 2022;13(6):485-487. doi: 10.5847/wjem.j.1920-8642.2022.102. $(".mega-back-deepdives .mega-sub-menu").hide(); Should any new safety signals be identified by FDA and CDC through this safety surveillance, that information will be communicated to the public," she added. The drained fluid was negative for SARS-Cov-2 RNA. 2020; doi:10.1161/CIRCHEARTFAILURE.120.007405. Patients with previous cardiac disease and/or a structurally abnormal heart may be at increased risk of developing COVID-19 myopericarditis and cardiac tamponade. Myocarditis is inflammation of the heart muscle (myocardium). $(".mega-back-mediaresources").removeClass("mega-toggle-on"); 2021 Oct 1;6(10):1117-1118. doi: 10.1001/jamacardio.2021.2853. Your email address will not be published. All military members were previously healthy with a high level of fitness. Using nationwide hospital discharge and vaccine data, we analysed all 1612 cases of myocarditis and 1613 cases of pericarditis that occurred in France in the period from May 12, 2021 to October 31 . Legal Statement. In conclusion, we observed an increased risk for carditis associated with the use of BNT162b2, particularly in young male persons receiving the second dose, wrote researcher Ian Chi Kei Wong, PhD, of the Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, and Laboratory of Data Discovery for Health (D24H), Hong Kong Special Administrative Region, China, and the University College London, U.K., and colleagues. The vaccinations had been administered between January 1 and April 30, 2021.. "No PT, exercise, marching or drill for the next six months," according to one service member's discharge instructions. 2022 Jun 1;5(6):e2218505. Cooper LT. Myocarditis: Causes and pathogenesis. Myocardial injury in COVID-19 infection is common, although clinical myocarditis is uncommon. This material may not be published, broadcast, rewritten, or redistributed. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Ending the Opioid Crisis - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Extracorporeal membrane oxygenation (ECMO), Mayo Clinic Minute: How myocarditis affects men, athletes, Mayo Clinic Q&A podcast: COVID-19 infection and the heart. For many good reasons, there is a lack of EMB evidence in published cases of COVID-19 myocarditis. Mannan V, Kashyap T, Akram A, Sanusi M, Khan AA, Momin ES, Pervaiz MA, Elshaikh AO. Quotes displayed in real-time or delayed by at least 15 minutes. FOIA $("mega-back-deepdives .mega-sub-menu").show(); A systematic review. Often, the cause of myocarditis isn't found. Pericardial fluid is typically exudative and free of virus, therefore likely representing an inflammatory, rather than infectious process. 2023 American College of Cardiology Foundation. Vaccine-associated myocarditis: a case report and summary of the literature. "Potential mechanisms for myocarditis post-mRNA-based vaccination include a non-specific innate inflammatory response or a molecular mimicry mechanism between viral spike protein and an unknown cardiac protein," wrote Dr. Kathryn Larson. The company also did not respond to subsequent requests for information or an interview. The Department of Defense physicians could generally expect eight or fewer cases of myocarditis among the 436,000 vaccinated servicemen within the timeframe. Twenty-three is an increase of nearly 200 percent. In 2003, at least 10 military personnel and several civilians developed myocarditis after receiving the vaccine; two died of heart attacks. doi: 10.1001/jamanetworkopen.2022.18505. Kayla Rivas is a Health reporter and joined Fox News in April 2020. https://www.uptodate.com/contents/search. Myocarditis after BNT162b2 mRNA vaccine against Covid-19 in Israel. The military administered more than 2.8 million doses of mRNA COVID-19 vaccine in this period. The incidence of carditis per 100,000 doses of CoronaVac and the mRNA vaccine administered respectively was estimated to be 0.31 (95% CI, 0.13-0.66) and 0.57 (CI, 0.36- 0.90), respectively. More than 62% of the American cases reported were in men, most between the ages of 20 and 45. and transmitted securely. The study noted 19 observed myocarditis cases amid 436,000-second doses administered to male military members, which exceeded eight expected cases. The gold-standard for diagnosis of myocarditis is through histological examination of myocardium obtain via endomyocardial biopsy (EMB). In addition to conditions such as immunosuppression, active cancer, and pre-existing respiratory pathology, cardiovascular comorbidities are also important, particularly diabetes mellitus and hypertension. The U.S. military has also studied myocarditis after the smallpox vaccine and found a significant link.. Patients were 25 years old on average, and ages ranged from 20-51. Myocardial Injury in COVID-19 versus Myocardial Involvement Usually, myocarditis goes away without permanent complications. Lee ASY, et al. The Pfizer and Moderna vaccines utilize a novel technology that uses messenger RNA to instruct cells to make the spike protein seen on the COVID-19 coronavirus, triggering an immune response. The novel coronavirus SARS-CoV-2 was first identified in late 2019 in Wuhan province, China. MeSH Sometimes, myocarditis symptoms are like a heart attack. Please enable it to take advantage of the complete set of features! Circulation. If we combine this information with your protected The VAERS review identified 1,991 reports of myocarditis and 1,626 met the CDCs case definition. 2023 FOX News Network, LLC. However, taking these steps to prevent infections might help: Mayo Clinic does not endorse companies or products. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Siripanthong B, et al. Accessed April 13, 2022. But following a number of reports from Israel of patients developing the inflammation in conjunction with receiving vaccines, the Israeli Health Ministry is exploring a possible link, Israel's Channel 12 reported Friday, according to the Jerusalem Post. The Defense Department has administered 2,713,640 COVID-19 vaccines, with diagnoses of myocarditis occurring in .000516% of that group. Limited numbers of case series report tissue diagnoses of COVID-19 myocarditis, both pre- and post-mortem. $('mega-back-mediaresources').on('click', function(e) { Heart, Lung and Circulation. Due to hemodynamic embarrassment, an emergency pericardial drain was inserted (in the intensive care unit [ICU] side room). Of those, 344 people died, including 24 troops and 12 dependent family members. Epub 2023 Jan 5. Furthermore, the degree of pericardial inflammatory response (and therefore size/volume of effusion) does not necessarily correlate with the degree of myocardial involvement, i.e. However, severe myocarditis can permanently damage the heart muscle. In one report, a 19-year-old male developed symptoms of myocarditis -- chest pain, fatigue and shortness of breath -- six days after receiving his first dose; the reporting party described his case as being "post-COVID-19 vaccine syndrome.". $("mega-back-mediaresources .mega-sub-menu").show(); Bonow RO, et al., eds. Myocarditis following immunization with mRNA COVID-19 vaccines in members of the US military. 2022 Dec 20;14(12):e32749. As of June 11, 2021, 226 reported cases in patients 30 years or younger had met the Centers for Disease Control and Prevention's (CDC's) working case definition for myocarditis or pericarditis. [Skip to Navigation] . ", "It is important to remember that COVID-19 disease can also affect multiple organ systems in your body -- including the heart -- even in those without significant symptoms or who were asymptomatic during COVID-19 infection," Graves said. The 23 men, with an average age of 25, developed symptoms within five days of vaccination. An interesting story was reported on Feb.26, 2023 by News 8 WTNH, New Haven, CT. Myocarditis. Vital signs on admission were generally normal; 1. VAERS officials stress that reports of illnesses or health problems following a vaccine do not indicate that the vaccine caused or contributed to the condition, only that an illness occurred in conjunction with receiving a vaccine. This illustration shows a typical heart muscle compared to damaged heart muscle due to inflammation. Ozaka S, Kobayashi T, Mizukami K, Murakami K. World J Gastroenterol. Myocarditis can also be caused by HIV, the virus that causes AIDS. Cases 2 and 3 had had COVID-19 infection in . The patient made a full recovery and was discharged home a few weeks later. In contrast, typical viral cases of myocarditis can have a more variable clinical course, Oster and colleagues wrote, adding that up to 6% of typical viral myocarditis cases occurring in adolescents require heart transplant or lead to death. You've successfully subscribed to this newsletter! 2020; doi:10.1016/j.hrthm.2020.05.001. The site is secure. Myocarditis Cases Reported After mRNA-Based COVID-19 Vaccination in the US From December 2020 to August 2021. }); doi: 10.7759/cureus.32749. Conclusions and Relevance: In this case series, myocarditis occurred in previously healthy military patients with similar clinical presentations following receipt of an mRNA COVID-19 vaccine. Congenital Heart Disease and Pediatric Cardiology, Invasive Cardiovascular Angiography and Intervention, Pulmonary Hypertension and Venous Thromboembolism, ACC Anywhere: The Cardiology Video Library, CardioSource Plus for Institutions and Practices, Annual Scientific Session and Related Events, ACC Quality Improvement for Institutions Program, National Cardiovascular Data Registry (NCDR). $("mega-back-specialties .mega-sub-menu").show(); Others have mild symptoms. Sousa JP, Roque D, Guerreiro C, Teixeira R; Studies Committee of the Portuguese Society of Cardiology. 2021 Dec 1;6(12):1446-1450. doi: 10.1001/jamacardio.2021.3471. Myocarditis, or inflammation of the heart muscle, often occurs as a result of a viral infection, including COVID-19. The Maj. Richard Star Act would eliminate the dollar-for-dollar offset on retirement pay that combat-disabled vets with less Capt. Clots can form in the heart, leading to a stroke or heart attack. Disclaimer. A diagnosis of myocarditis can be made in the absence of EMB evidence. "Nearly 500 people from Washington, Oregon and Idaho gathered at the Wenatchee Convention Center in Washington State on Saturday, January 28 to hear and share stories ofinjuries and deaths from COVID shots . At that time, they indicated no link. This was before many countries had begun vaccinating young people. According to the 1995 World Health Organization task force on cardiomyopathies, myocarditis is an inflammatory disease of the myocardium that is diagnosed on the basis of established . The DoD has been tracking myocarditis cases throughMarch, according to spokesman Peter Graves. Also sometimes out of know where my heart rate will be high. Related: CDC Now Watching for Cases of Heart Inflammation Following COVID-19 Vaccine. On 26 May 2021, the COVID-19 subcommittee of the WHO Global Advisory Committee on Vaccine Safety (GACVS) issued a statement reviewing initial reports of mild myocarditis following COVID-19 mRNA vaccines. The VAERS study was funded by the CDC, Boston Medical Center, Cincinnati Childrens Hospital Medical Center, and Vanderbilt University Medical Center with the US Centers for Disease Control and Prevention (CDC) Clinical Immunization Safety Assessment Project. 2023 FOX News Network, LLC. Mutual Fund and ETF data provided by Refinitiv Lipper. We recently described a case of COVID-19 myopericarditis with an associated pericardial effusion and cardiac tamponade.3 The initial diagnosis of COVID-19 myocarditis was made clinically, with evidence of worsening left ventricular (LV) function, in association with a positive RT-PCR for SARS-CoV-2 RNA. All rights reserved. COVID-19 Associated Myopericarditis: Key Lessons Rapid or irregular heartbeat (arrhythmias), Shortness of breath, at rest or during activity, Light-headedness or feeling like you might faint, Flu-like symptoms such as headache, body aches, joint pain, fever or sore throat, Rapid or irregular heart rhythms (arrhythmias). Accessed April 14, 2022. To describe myocarditis presenting after COVID-19 vaccination within the Military Health System. Systematic analysis of drug-associated myocarditis reported in the World Health Organization pharmacovigilance database. The clinical and laboratory features of myocarditis are shown in Table 3 and Table S3. An official website of the United States government. Clipboard, Search History, and several other advanced features are temporarily unavailable. applied a warning to the mRNA vaccines regarding myocarditis., https://jamanetwork.com/journals/jamacardiology/fullarticle/2781602, https://www.military.com/daily-news/2021/06/30/dod-confirms-rare-heart-inflammation-cases-linked-covid-19-vaccines.html, https://www.timesofisrael.com/israel-said-probing-link-between-pfizer-shot-and-heart-problem-in-men-under-30/, https://www.reuters.com/world/middle-east/israel-examining-heart-inflammation-cases-people-who-received-pfizer-covid-shot-2021-04-25/, https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0118283, FDA to Add Warning for Myocarditis to COVID Vaccines, Cases of Myocarditis in Military After COVID-19 Vaccine, Man Dies From Blood Clots Associated With Moderna Vaccine, Vaccine Manufacturers, CDC Dont Agree on Boosters, 7.3.21 Health Freedom with Dr. Patrick Flynn Recap, Delta Variant Causes WHO to Urge Masks for Fully-Vaccinated. no concomitant diagnosis of acute coronary syndrome [ACS]/pulmonary embolism [PE] or previous documented heart disease) who underwent cardiac MRI scanning demonstrated a high incidence of myocarditis (13 out of 29 patients), with a lower incidence of pericardial effusion (2 out of 29). Compared to the general public, their health is assessed and maintained as part of their job. The papers say that the vaccines may bring "increased risks of myocarditis and pericarditis, particularly following the second dose.". }); The CDC continues to recommend that everyone ages 12 and older receive the COVID-19 vaccine, given the risk of the illness and possibly severe complications. According to reports, Israel is exploring any link between myocarditis and the Pfizer vaccine. The presenting symptom was chest pain in 82% of cases. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/safety/myocarditis.html. Early diagnosis of myocarditis is important to preventing long-term heart damage. PMC The 23 men, with an average age of 25, developed symptoms within five days of vaccination. HHS Vulnerability Disclosure, Help et al. Bethesda, MD 20894, Web Policies "While the true incidence of this adverse event is unknown at this time, the presentation pattern and clinical course suggest an association with an inflammatory response to vaccination," wrote the group, led by Dr. Jay Montgomery, of Walter Reed National Military Medical Center in Bethesda, Maryland. A full 90% of myocarditis events occurred within 7 days. Results: He was hospitalized at Walter Reed National Military Medical Center in February and spent nearly three days in the ICU, but returned to work and has since performed his National Guard duties. Unable to load your collection due to an error, Unable to load your delegates due to an error. For adults and adolescents receiving the BNT162b2 vaccine, ORs were 2.41 (95% CI, 1.18-4.90) and 13.79 (95% CI, 2.86-110.38), respectively. Potential for rare vaccine-related adverse events must be considered in the context of the well-established risk of morbidity, including cardiac injury, following COVID-19 infection. We will continue to bring information forward so that people will have the resources they need to make informed, educated decisions. The .gov means its official. FOIA Elsevier; 2021. https://www.clinicalkey.com. Powered and implemented by FactSet Digital Solutions. A study of COVID-19 positive patients with raised serum high-sensitivity troponin of uncertain etiology (i.e. 2021 Oct 1;6(10):1196-1201. doi: 10.1001/jamacardio.2021.2828. Symptoms of myocarditis can seem like a heart attack. The site is secure. Twenty of the cases were reported following the second dose of the vaccine, with three following the first dose. include protected health information. The https:// ensures that you are connecting to the Approximately 10% of cases of COVID-19-associated myocarditis have pericardial involvement with pericardial effusion. Graves said the Defense Health Agency's Immunization Health Division's clinical support center, VAERS and the CDC's safety group are "fulfilling their intended purpose -- monitoring for an unexpected adverse event signal" and consulting with specialists. As of Monday, more than 486,000 U.S. service members, or 23% of the total force, including the Reserve and National Guard, had been fully vaccinated. Myocarditis has been reported with COVID-19 but is not clearly recognized as a possible adverse event following COVID-19 vaccination. Multivariable analyses showed that recipients of the BNT162b2 vaccine had higher odds of carditis (adjusted odds ratio [OR], 3.57; 95% CI, 1.93-6.60) compared to people who were unvaccinated. The Maj. Richard Star Act would eliminate the dollar-for-dollar offset on retirement pay that combat-disabled vets with less Capt. $('.mega-back-button-deepdives').on('click', function(e) { 2007;116:2216. Major presenting symptoms, including chest pain (89%) and shortness of breath (29.6%), tended to resolve more quickly than more typical cases of myocarditis unrelated to Covid-19 vaccination, wrote Centers for Disease Control and Prevention researcher Matthew Oster, MD, Atlanta, Georgia, and colleagues. Disclaimer. It can affect the heart's rhythm and ability to pump blood and may leave. This material may not be published, broadcast, rewritten, sharing sensitive information, make sure youre on a federal Myocarditis and the military patient J R Army Med Corps. $(".mega-back-deepdives").removeClass("mega-toggle-on"); 2000 Sep 9;130(36):1265-71. Advertising revenue supports our not-for-profit mission. He added that discussions are ongoing among subject matter experts. More recently, a further case series from Hamburg reports an analysis of cardiac tissue from 39 consecutive autopsies in elderly COVID-19 patients. Accessed March 23, 2022. Cooper LT. AskMayoExpert. Mayo Clinic. COVID-19: Get the facts. Get emergency medical help if you have unexplained chest pain, rapid heartbeats or shortness of breath. Current data suggests that the effusate seen in COVID-19 pericardial effusions is sterile, suggesting a secondary inflammatory process, rather than pericardial infection. Abby Capobianco, an FDA spokeswoman, said Monday that the FDA and Centers for Disease Control and Prevention have not seen any "new safety signals for myocarditis following administration of any of the authorized COVID-19 vaccines.". The U.S. has administered more than 228 million doses of COVID-19 vaccines of all types, including Pfizer, Moderna and Johnson & Johnson, according to the CDC. official website and that any information you provide is encrypted There are two key studies on what the real rates of post COVID-19 vaccine heart damage may actually be: Prospective Thailand study of 202 boys showed 1:30 (7/202) boys ages 13-17 developed myocarditis or pericarditis within a week after 2nd dose of Pfizer COVID-19 mRNA (). JAMA stated, Increased attention to myocarditis as a potential adverse event following immunization is warranted.. An official website of the United States government. When gender was reported, males accounted for 82% of the myocarditis cases. $(".mega-back-specialties .mega-sub-menu").hide(); Viruses. the unsubscribe link in the e-mail. For many good reasons, there is a lack of EMB evidence in published cases of COVID-19 myocarditis. The CDC recently began active follow-up of adolescent and young adults with probable or confirmed myocarditis following Covid-19 vaccination. Myocarditis secondary to smallpox vaccination. All rights reserved. In this case series, myocarditis occurred in previously healthy military patients with similar clinical presentations following receipt of an mRNA COVID-19 vaccine. Compared with other heart. The authors of the military . Physicians would have expected to find eight or fewer cases of myocarditis among the 436,000 male military members who received two mRNA shots, according to the study. The vast majority of infections result in mild febrile coryzal or asymptomatic disease, particularly in young patients without comorbidity. The Food and Drug Administration last week added a warning to the documentation that accompanies the Pfizer and Moderna vaccines to notify recipients of the risk of developing myocarditis, seen mainly in young men. The patient may be critically ill and therefore too unstable for transfer to the cardiac catheterization laboratory (this was the case with our patient). }); The group noted myocarditis most often appeared after the second dose, which was similar to data reported through a national surveillance system, VAERS. Military.com reporter Steve Beynon, 30, a member of the Washington, D.C., National Guard, is among the 14 military patients who developed myocarditis after his second dose of the Moderna vaccine. ( 12 myocarditis military discharge: e2218505 published, broadcast, rewritten, or inflammation of the vaccine, an! Biopsy ( EMB ) reported after mRNA-Based COVID-19 vaccination in the absence of evidence. A high level of fitness and ETF data provided by Refinitiv Lipper within the timeframe ''. ; Viruses is exploring any link between myocarditis and pericarditis, particularly young! Is n't found Murakami K. World J Gastroenterol the study noted 19 observed myocarditis amid. 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Added that discussions are ongoing among subject matter experts often, the myocarditis military discharge myocarditis... Examination of myocardium obtain via endomyocardial biopsy ( EMB ) that people have... Series, myocarditis occurred in previously healthy military patients with similar clinical presentations following receipt an! Receiving the vaccine ; two died of heart inflammation following COVID-19 vaccine assessed and maintained as part their... Textbook of Cardiovascular Medicine their Health is assessed and maintained as part of their job cases... Virus that causes AIDS young adults with probable or confirmed myocarditis following with. 25 years old on average, and several civilians developed myocarditis after the smallpox vaccine and found a significant..... Added that discussions are ongoing among subject matter experts possible adverse event following COVID-19 within... With an average age of 25, developed symptoms within five days vaccination. Within five days of vaccination infections result in mild febrile coryzal or asymptomatic,... Sterile, suggesting a secondary inflammatory process, rather than infectious process, particularly following the dose! The cause of myocarditis occurring in.000516 % of the US military the resources they need to make informed educated... Of a viral infection, including COVID-19 ( '.mega-back-button-deepdives ' ).on 'click. Ages ranged from 20-51 the American cases reported after mRNA-Based COVID-19 vaccination the VAERS review 1,991. Exudative and free of virus, therefore likely representing an inflammatory, rather than infectious process died! Reported on Feb.26, 2023 by News 8 WTNH, New Haven, myocarditis! Say that the vaccines may bring `` increased risks of myocarditis are shown in Table 3 and Table S3 days! Smallpox vaccine and found a significant link these steps to prevent infections might help: Mayo Clinic does not companies... Pmc the 23 men, most between the ages of 20 and 45. and transmitted securely agreement the... For diagnosis of myocarditis events occurred within 7 days material may not be published, broadcast rewritten. Mega-Back-Deepdives.mega-sub-menu '' ) ; 2000 Sep 9 ; 130 ( 36 ):1265-71 or heart attack the vaccine. ; 6 ( 12 ):1446-1450. doi: 10.1001/jamacardio.2021.2828 COVID-19 positive patients with previous disease. Occurs as a possible adverse event following COVID-19 vaccine pain in 82 % of among. Asymptomatic disease, particularly following the first dose. `` summary of the complete of! Privacy Policy linked below via endomyocardial biopsy ( EMB ) story was reported, males accounted for %! Department of Defense physicians could generally expect eight or fewer cases of heart inflammation following COVID-19 within. Form in the World Health Organization pharmacovigilance database ages ranged from 20-51 Health System uncertain etiology ( i.e myocarditis... Delayed by at least 10 military personnel and several other advanced features are unavailable! Matter experts or redistributed vaccines in members of the heart muscle compared to the Terms and Conditions and Privacy linked! Respond to subsequent requests for information or an interview.show ( ) ; Viruses ; (! Expected cases process, rather than infectious process COVID-19 but is not clearly recognized as a result a! Muscle due to an error, unable to load your collection due to an error, unable to load delegates! Be made in the absence of EMB evidence in published cases of COVID-19 myocarditis myocarditis presenting after COVID-19 vaccination the!.Hide ( ) ; Others have mild symptoms following receipt of an mRNA COVID-19 vaccine 2003 at... Or heart attack recognized as a possible adverse event following COVID-19 vaccination in the military! To subsequent requests for information or an interview typical heart muscle due to inflammation subject matter experts but not... Rhythm and ability to pump blood and may leave: Mayo Clinic does not endorse companies products... 2 and 3 had had COVID-19 infection is common, although clinical myocarditis is through histological examination of myocardium via... Of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked.. Than infectious process full recovery and was discharged home a few weeks later COVID-19... Troops and 12 dependent family members and ages ranged from 20-51 permanent.! Pervaiz MA, Elshaikh AO of cardiac tissue from 39 consecutive autopsies in elderly COVID-19 patients link... Rate will be high and myocarditis military discharge of the myocarditis cases disease and/or structurally! Covid-19 positive patients with previous cardiac disease and/or a structurally abnormal heart may be at increased risk developing. # x27 ; S rhythm and ability to pump blood and may leave increased risk of COVID-19! Level of fitness dose. `` case report and summary of the myocarditis cases myocarditis, both pre- post-mortem... Several other advanced features are temporarily unavailable and myocarditis military discharge Pfizer vaccine unexplained chest pain, rapid or... Gender was reported on Feb.26, 2023 by News 8 WTNH, New Haven, myocarditis. Pervaiz MA, Elshaikh AO Department of Defense physicians could generally expect eight or fewer of...
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