It is based on amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate and alpha - gpc (the active ingredients of Adderall and L-alpha-glycerylphosphorylcholine, respectively), and Adderall and L-alpha-glycerylphosphorylcholine (the brand names). For the very first 20-25 minutes, I really did not really feel any kind of effects. [25] Alpha-GPC is considered to be a more effective (assessed by potency on a weight basis) cholinergic than both choline and CDP-choline when looking at serum values or benefit from clinical interventions. Mentioning which, these products arent only beneficial for cognitive tasks. Theyre likewise terrific for exercise. AC-11 is Onnits trademarked formula of this removal.Can You Take Alpha Brain With Adderall? ( A , B, GPC promotes atherosclerosis. Circ Res. Adderall has not been found to interact negatively with any supplements. No interactions were found between Adderall and vitamins, including Vitamin D, Vitamin C, Vitamin B12, and niacin (B3). Adderall has also never been found to negatively interact with any minerals commonly found in multivitamin or nootropic supplement stacks. Scopolamine (Transderm Scop)Interaction Rating: Minor Be cautious with this combination.Talk with your health provider. Unauthorized use of these marks is strictly prohibited. ( A ) SDS-PAGE/Western blotting, GPC supplementation alters the plasma concentration of gut microbial metabolites implicated in the, Untargeted metabolomic analysis of plasma, Untargeted metabolomic analysis of plasma metabolites in GPC supplemented chow diet-fed mice versus, Schematic Figure showing GPC promoting atherosclerosis through multiple mechanisms. There is no drug interaction reported. Whether a supplement is mosting likely to create side effects and exactly how severe those side effects are constantly depends upon the serving sizes of the components. This can ensure youre taking lisinopril with other medications safely. A randomized, double-blind, placebo controlled, parallel group, efficacy study of Alpha Brainadministered orally. Bacopa is a natural herb that aids boost cognition & mental abilities by aiding alleviate stress and anxiety as well as boosting memory feature. Gut Microbiota and Cardiovascular Disease. We currently have no information for ALPHA-GPC overview. If you desire your brain to work much better, you require to focus on two things: getting it to make more alpha waves, and also supporting the manufacturing of neurotransmitters. It is still unclear whether alpha-GPC has additional benefits over approved Alzheimers medications. It was amongst the first brain supplements to go mainstream. L-alpha-glycerylphosphorylcholine (shortened to Alpha-GPC usually, also known as choline alphoscerate or glycerophosphocholine) is a choline containing phospholipid[16] and an intermediate of lecithin metabolism or simply a lecithin molecule with two less fatty acids. 2020;68:1237512383. Voigt RM, Wang Z, Brown JM, Engen PA, Naqib A, Goetz CG, Hall DA, Metman LV, Shaikh M, Forsyth CB, Keshavarzian A. Neurobiol Dis. [39], One other study has reported that 600mg Alpha-GPC taken 45 minutes prior to physical exercise is able to augment the exercise-induced growth hormone spike from 5.0+/-4.8ng/mL in placebo to 8.4+/-2.1 ng/mL with supplementation. In turn, CDP-choline has a broader range of potential benefits, but alpha-GPC may have an edge in boosting physical and mental performance [16, 17]. For attenuating symptoms of cognitive decline, almost all studies used a dosage of 1,200 mg per day, divided into three doses of 400 mg. For boosting power output, studies have used a dosage of 300600 mg, supplemented 3060 minutes prior to exercise. This happens all day long on alpha gpc. View abstract. GPC is abundant in the gut. See this image and copyright information in PMC. Personalize this study to your gender and age, Methylprednisolone and Post Lumbar Puncture Syndrome, Trandolapril and Acetaminophen drug interaction, Cascara Sagrada and Hot Flushes Aggravated, Levaquin and Giant Cell Tumor Of Tendon Sheath, Saw Palmetto and Tinidazole drug interaction. js = d.createElement(s); js.id = id; Information from this source is evidence-based and objective, and without commercial influence. >>>CLICK HERE TO GET A FREE TRIAL OF ONNIT ALPHA BRAIN TODAY<<<. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. eHealthMe is studying from 55,787 Adderall users for its effectiveness, alternative drugs and more. It is phosphatidylcholine (a lecithin molecule) without its two fatty acids. Individuals take nootropics to boost their cognitive functions. [63][66] This is thought to be a part of pathology since the traditional biomarker of Alzheimer's disease, -amyloid proteins, can activate phospholipase A2 in neurons[67] and accelerate phospholipid degradation due to this. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. I obtained a moderate energy press, which amazed me.. a cholinergic compound that is used for cognitive-enhancement, and to increase power output in athletes. [49], Can possibly increase brain acetylcholine levels, although this may be localized to the frontal cortex. Alpha-GPC is another option; this compound is very similar to Citicoline, except it also contain phospholipids which support brain cell formation and maintenance. Neurons that produce acetylcholine are some of the first neurons lost in Alzheimers disease, and theoretically, taking alpha-GPC may compensate for that loss. Recent researches conducted by the Boston Facility for Memory showed that Alpha Brain carried out in reality help sharpen emphasis and memory when contrasted to sugar pill. View abstract. The peak effect is observed using 600 mg/kg IG, 5 h before training. In one open-label study, patients with mild cognitive impairment reported that alpha-GPC treatment slightly improved cognition over 90 days, and this effect appeared to be more pronounced in patients without APOE4, the genetic risk factor for Alzheimers disease [2]. First, we really need to understand how the brain works in order to understand how nootropics function. WebAlpha GPC (alpha-glycerylphosphorylcholine) is found naturally in your brain. Dosage of drugs is not considered in the study. At six weeks, significant improvement was noted in tasks of delayed verbal recall and executive functioning for the Alpha BRAINgroup compared to placebo (p < 0.05). -. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you. [39], Phosphocholine (200-300nmol/g) and glycerophosphocholine (500-600nmol/g) concentrations in neural tissue are relatively higher than that of free choline or acetylcholine itself (less than 30nmol/g collectively),[40][41][42], Free choline and acetylcholine are relatively low in neural tissue, whereas concentrations of storage forms of choline (phosphocholine and Alpha-GPC) are relatively higher, It has been noted that the concentrations of glycerophosphocholine found in the brain is comparable or slightly lesser than that found in the blood, suggesting fairly easy passage via the blood brain barrier. Before Alpha-GPC increases a chemical in the No evidence directly assessing the interactions of Alpha-GPC and glutaminergic neurotransmission, but theoretically it can be neuroprotective (a trait common to choline containing compounds), Alpha-GPC has been implicated in GABA release via the noradrenergic system. [60], Alpha-GPC does not appear to influence forskolin or noradrenaline-induced adenyl cyclase activity. Wang Z, Hazen J, Jia X, et al. 2022 Aug 16;14(16):3349. doi: 10.3390/nu14163349. My thoughts come to me as if I were to speak or take actions and in a split second it's gone, and I'm beating my self up over what it is that I just forgot that I had to say or do. Essential: If youre pregnant, nursing or have a medical problem/ on medicines, get in touch with a medical physician before taking Alpha Brain of various other supplements. The Boston University research study showed that Alpha BRAIN customers had 12% better spoken recall. (, GPC activates NFB and MAPK signaling in HCAEC. doi: 10.1021/acs.jafc.0c06381. ( A, GPC activates NFB and MAPK signaling in HCAEC. Even though Alpha Brain is marketed as a natural item, its usage develops a synthetic adjustment in the brain. I do not understand exactly what happened, but she really did not such as the impacts.. Instead of attempting to stack your nootropic concoction together, Alpha Brain does it for you and is accredited drug cost-free. 8600 Rockville Pike Both Alpha-GPC (150mg/kg and CDP-Choline are able to increase the dopamine transporter in these brain regions. Appears excellent to me!Can You Take Alpha Brain With Adderall? The most common active ingredient in Alpha Brain is alpha GPC, which is known to interact with medications that affect blood clotting. fjs.parentNode.insertBefore(js, fjs); The phase IV clinical study analyzes what interactions people who take Adderall and L-alpha-glycerylphosphorylcholine have. (2019), Gavrilova SI, Kolykhalov IV, Ponomareva EV et al. I used to only take 300 mg of AGPC once daily. However, no studies have examined whether alpha-GPC improves cognition in healthy individuals or prevents Alzheimers disease. Gut microbial metabolites in Parkinson's disease: Association with lifestyle, disease characteristics, and treatment status. [72] While Alpha-GPC at the therapeutic dosage (1200mg daily) was more effective in the one trial where it was compared against ALCAR (a variant of L-Carnitine),[73] it seems to be either more potent or equally effective to oxiracetam. This instability (albeit mild) can impact my mental health and/or really put a damper on some days. var js, fjs = d.getElementsByTagName(s)[0]; [45] This has been confirmed in a pilot study in otherwise healthy humans where the amnesiac effects of scopolamine were ablated, and appeared to be due to the cholinergic properties as amnesia via benzodiazepines was not affected. Taking alpha GPC could lead to improved vitality and increased strength as it helps muscles recover after exercise. Adderall can be highly addictive and cause a variety of side effects. New comments cannot be posted and votes cannot be cast. (2018), Tayebati SK, Amenta F, Tomassoni D (2015), Amenta F, Carotenuto A, Fasanaro AM et al. [62] The potency of 600mg/kg Alpha-GPC in activating PKC is similar to 100mg/kg oxiracetam and 30mg/kg Aniracetam (higher doses being ineffective). Disclaimer. 2022 Aug;170:105780. doi: 10.1016/j.nbd.2022.105780. Cats Claw is an amazonian herb that has cognitive enhancing abilities. For me, my focus was increased. I didnt experience unfavorable impacts like an upset stomach or wild lucid dreams like I have actually seen reported by others. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. }(document, "script", "aweber-wjs-e17dm7rdw")); https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4595564/, What Alpha Brain Does Joe Rogan Take? If you are seeking to enter your area or flow state much more regularly to ensure that you can deal with jobs with optimum performance, after that you must include Alpha Brain to your program. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). I felt much more concentrated, and I was much more stimulated. (, Bacterial taxa in mouse cecum that significantly correlate to either plasma TMAO level or aortic lesion area. Revisiting the Cholinergic Hypothesis in Alzheimer's Disease: Emerging Evidence from Translational and Clinical Research, [Clinical efficacy and safety of choline alfoscerate in the treatment of late-onset cognitive impairment], Effect of a new cognition enhancer, alpha-glycerylphosphorylcholine, on scopolamine-induced amnesia and brain acetylcholine, Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate: a multicenter, double-blind, randomized, placebo-controlled trial, The delaying effect of alpha-glycerophosphocholine on senescence, transthyretin deposition, and osteoarthritis in senescence-accelerated mouse prone 8 mice, Cerebrovascular and blood-brain barrier morphology in spontaneously hypertensive rats: effect of treatment with choline alphoscerate, The ASCOMALVA (Association between the Cholinesterase Inhibitor Donepezil and the Cholinergic Precursor Choline Alphoscerate in Alzheimer's Disease) Trial: interim results after two years of treatment, Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data, One open-label study in patients with mild cognitive impairment, Two randomized controlled trials in patients with mild to moderate Alzheimers/dementia, One review of previous trials in patients with dementia or cerebrovascular disease, Preclinical studies on the use of alpha-GPC, Hampel H, Mesulam MM, Cuello AC et al. 2022 Nov;59(11):6684-6700. doi: 10.1007/s12035-022-02990-5. This information may not fit your specific health circumstances. [72] Of these trials, the largest can be located online. Other potential side effects include heartburn, headache, insomnia, dizziness, skin rash, and confusion [9]. Coolmango8 6 yr. ago I take vyvamse and the days I add alpha gpc, I get massive brain fog. Although some studies suggest that alpha-GPC may improve cognition in dementia patients, many of these studies were conducted before widespread use of currently approved Alzheimers drugs that are designed to increase acetylcholine levels. At $80 a container, this nootropic can be costly. Gatti G, Barzaghi N, Acuto G, et al. To do virtually anything, our minds call for a neurotransmitter release; more particularly, they need a details electric capacity to prompt the activation of a nerve impulse.The neurotransmitters require to be gotten by the receptors for anything to take place. (. Whether you are an athlete, entrepreneur, imaginative, etc., this product can assist you do what you need to do at a higher level. P. mirabilis , E., GPC is abundant in the gut. We do not understand all of the component doses in Alpha Brain, so we can not be certain when it comes to side effect risks.This is a large trouble. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. View abstract. Wang and Hazen report having received royalty payments for inventions or discoveries related to cardiovascular diagnostics or therapeutics from Cleveland Heart Lab, a fully owned subsidiary of Quest Diagnostics, and Procter & Gamble. Lipoic Acid enhances insulin-stimulated glucose transport and metabolism for better brain cell performance. [55], Protein Kinase C (PKC) is an intracellular intemediate that appears to be associated with memory formation when activated[56][57] and is involved in long term potentiation as well. Alpha-GPC can also be formed as a byprodut when two molecules of lysolecithin reconfigure into a molecule of lecithin[17][37] (via an acetylation that is active when high concentrations of lysolecithin are present, with a KM of 3.6mM[38]). [70], 1,000mg Alpha-GPC has elsewhere been shown (intramuscular injections) to have benefit in vascular dementia over 90 days in regards to behavioural, memory, and verbal symptoms. It is possible that alpha-GPC decreases the effects of scopolamine, but it's not clear if this actually happens. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. GPC and choline distribution in the mouse, GPC supplementation increases cecal TMA and plasma TMAO production. In this Alpha Brain Review, we will certainly see what this preferred nootropic is, just how it functions, and also whether it deserves acquiring.Can You Take Alpha Brain With Adderall? There are many nootropics available that offer total formula openness why use one that doesnt? Immobilized Phospholipase A1-Catalyzed Preparation of l-alpha-Glycerylphosphorylcholine from Phosphatidylcholine. It originates from the water hyssop. Alpha-GPC is generally well tolerated. View abstract. [61], Administration of Alpha-GPC to rats has been noted to promote PKC translocation in the rat cortex at an oral dose of 600mg/kg[59] peaking at one hour after oral administration[60][62] and either normalizing or dipping below control 5 hours after ingestion. The site is secure. [53][54], In vitro, 1.2mM but not 0.12mM was effective in increasing spontaneous GABA release from neurons and was again inhibited by prazosin. Your use of this site constitutes your agreement to the Terms & Conditions. However, no further studies have confirmed there is value adding alpha-GPC to approved Alzheimers drugs or whether it would be safe. [4][5] Additionally, a pilot study reported that alpha-GPC increased peak bench press force, but not peak power or rate of force development. It could enhance our response to workouts and workout regimens.Can You Take Alpha Brain With Adderall? [46] Along these lines, Alpha-GPC has been found to potentiate potassium-invoked calcium release in the hippocampus and receptor-mediated production of inositol phosphate,[47] which is a similar phenomena as seen with uridine (which is thought to act via support phospholipids). I ordered a 90-capsule bottle as well as I couldnt wait on the test to start.. It's generally well-tolerated, but some people may experience side effects like headaches, dizziness, and gastrointestinal distress. This is the sort of club moss that contains & produces Huperzine A. Huperzine is from a plant called Chinese club moss and also is developed to aid wth increase memory & brainpowers. In healthy individuals or prevents Alzheimers disease G, barbagallo M, al... Very first 20-25 minutes, I really did not such as the impacts muscles after. Mapk signaling in HCAEC on natural medicines, see natural medicines Comprehensive Database professional.... However, no further studies have confirmed there is value adding alpha-GPC to approved Alzheimers medications phosphatidylcholine a! Comprehensive Database professional Version, these products arent only beneficial for cognitive tasks unclear whether alpha-GPC has additional benefits approved! Interact negatively with any minerals commonly found in multivitamin or nootropic supplement.. Wait on the test to start confusion [ 9 ] it would be safe choline distribution in the works. Activates NFB and MAPK signaling in HCAEC concentrated, and niacin ( )! I really did not such as the impacts ( B3 ):3349.:... To increase the dopamine transporter in these brain regions understand how the brain works in order understand.: Association with lifestyle, disease characteristics, and treatment status and more, we really need to how! Not understand exactly what happened, but some people may experience side effects like headaches, dizziness, skin,! The brain works in order to understand how the brain works in order understand. Brainadministered orally still unclear whether alpha-GPC improves cognition in healthy individuals or prevents Alzheimers.... Be posted and votes can not be cast brain TODAY < < < < < youre taking lisinopril with medications. Be localized to the frontal cortex not understand exactly what happened, but she really did really! Muscles recover after exercise 9 ] skin rash, and I was much more stimulated to negatively with. This nootropic can be costly ( Transderm Scop ) Interaction Rating: Minor be with... Confirmed there is value adding alpha-GPC to approved Alzheimers drugs or whether it would safe. Mental abilities by aiding alleviate stress and anxiety as well as boosting memory feature alpha-GPC does appear! Massive brain fog combination.Talk with your health effects like headaches, dizziness, skin rash, and niacin ( )... Is possible alpha gpc and adderall interaction alpha-GPC decreases the effects of scopolamine, but some may. Not clear if this actually happens but some people may experience side effects the test to... Vitamin B12, and gastrointestinal distress abilities by aiding alleviate stress and anxiety as well as boosting memory feature well-tolerated! Is possible that alpha-GPC decreases the effects of scopolamine, but some people may side... Be located online L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years with subsequent stroke risk 10... But she really did not such as the impacts instability ( albeit mild ) can impact my health... Heartburn, headache, insomnia, dizziness, skin rash, and treatment status for its,... Stack your nootropic concoction together, Alpha brain TODAY < < < < < GPC. Gavrilova SI, Kolykhalov IV, Ponomareva EV et al to your health considered in the study disease! What interactions people who Take Adderall and L-alpha-glycerylphosphorylcholine have however, no further have... Once daily to interact negatively with any minerals commonly found in multivitamin nootropic... Acid enhances insulin-stimulated glucose transport and metabolism for better brain cell performance brain customers had 12 % spoken! In multivitamin or nootropic supplement stacks amazonian herb that aids boost cognition & mental by... Or aortic lesion area alpha-GPC improves cognition in healthy individuals or prevents Alzheimers disease well-tolerated... Information on natural medicines, see natural medicines, see natural medicines Comprehensive Database professional Version 9 ] objective and. Nootropic can be highly addictive and cause a variety of side effects like,! Massive brain fog and the days I add Alpha GPC could lead to improved vitality increased... For professional medical information on natural medicines, see natural medicines, see natural medicines see... Vitamin D, Vitamin B12, and niacin ( B3 ) decreases the effects of scopolamine but... Parallel group, efficacy study of Alpha Brainadministered orally two fatty acids dosage of is. Cognition in healthy individuals or prevents Alzheimers disease to me! can Take! Health and Human Services ( HHS ) 20-25 minutes, I really did not really any! Effects of scopolamine, but some people may experience side effects include,... Comments can not be posted and votes can not be cast cats Claw an! Risk after 10 Years some days what interactions people who Take Adderall and L-alpha-glycerylphosphorylcholine.... So could be hazardous to your health provider could lead to improved vitality and increased strength as it helps recover... Appears excellent to me! can You Take Alpha brain with Adderall Aug 16 ; 14 ( 16:3349.... Clear if this actually happens it is phosphatidylcholine ( a lecithin molecule ) without its two fatty acids the effect... G, barbagallo M, et al go mainstream more stimulated and choline in..., Jia X, et al ( B3 ) ; 14 ( 16 ):3349. doi:.! Considered in the study in healthy individuals or prevents Alzheimers disease, its usage develops a alpha gpc and adderall interaction adjustment in study! Is an amazonian herb that has cognitive enhancing abilities instead of attempting to stack nootropic. From this source is evidence-based and objective, and treatment status STOP medications first! Medicines Comprehensive Database professional Version gut microbial metabolites in Parkinson 's disease: Association with lifestyle, disease characteristics and. First brain supplements to go mainstream brain cell performance trademarks of the U.S. Department of and... The study found in multivitamin or nootropic supplement stacks ( 150mg/kg and CDP-Choline able. Showed that Alpha brain customers had 12 % better spoken recall Pike Both alpha-GPC 150mg/kg. Medicines Comprehensive Database professional Version mouse, GPC activates NFB and MAPK signaling in HCAEC naturally in brain! Pubmed wordmark and PubMed logo are registered trademarks of the U.S. Department of and... And gastrointestinal distress that aids boost cognition & mental abilities by aiding alleviate stress and as. Boosting memory feature improved vitality and increased strength as it helps muscles recover after.! Ig, 5 h before training well-tolerated, but it 's not clear this... Is found naturally in your brain risk after 10 Years and votes can not cast... = d.createElement ( s ) ; the phase IV clinical study analyzes what interactions people who Take Adderall and,! Rash, and treatment status of side effects like headaches, dizziness, and without influence! Is marketed as a natural item, its usage develops a synthetic adjustment in the gut a variety of effects... Reported by others and L-alpha-glycerylphosphorylcholine have clear if this actually happens TMAO production some.., placebo controlled, parallel group, efficacy study of Alpha Brainadministered orally taking... Some people may experience side effects like headaches, dizziness, skin rash, and confusion 9., placebo controlled, parallel group, efficacy study of Alpha Brainadministered orally trademarks of the U.S. Department of and.: 10.3390/nu14163349 drugs is not considered in the brain additional benefits over Alzheimers... Frontal cortex, 5 h before training at $ 80 a container, this nootropic can be.! Be highly addictive and cause a variety of side effects include heartburn, headache,,! But some people may experience side effects observed using 600 mg/kg IG, 5 h before training has never. Amazonian herb that aids boost cognition & mental abilities by aiding alleviate stress and anxiety as well as boosting feature. Of AGPC once daily, Alpha brain with Adderall is not considered in the gut of health and Human (... Once daily physician since doing so could be hazardous to your health that correlate! Onnit Alpha brain customers had 12 % better spoken recall, can possibly increase brain acetylcholine levels, although may! May not fit your specific health circumstances arent only beneficial for cognitive tasks L-alpha-glycerylphosphorylcholine have possible that alpha-GPC decreases effects... Medications that affect blood clotting, Bacterial taxa in mouse cecum that significantly correlate to either plasma level... Have actually seen reported by others but some people may experience side effects by aiding alleviate stress and as! Phosphatidylcholine ( a lecithin molecule ) without its two fatty acids ehealthme is studying from 55,787 Adderall for! Helps muscles recover after exercise ; 59 ( 11 ):6684-6700. doi:.! Well-Tolerated, but some people may experience side effects whether it would be safe et.... Marketed as a natural herb that aids boost cognition & mental abilities by alleviate., although this may be localized to the Terms & Conditions removal.Can Take. Naturally in your brain increased strength as it helps muscles recover after exercise she really did not really any! Or wild lucid dreams like I have actually seen reported by others new can..., this nootropic can be located online, Acuto G, barbagallo M, et al wait on test... Of drugs is not considered in alpha gpc and adderall interaction brain works in order to understand how nootropics function Take mg... ) can impact my mental health and/or really put a damper on some days though Alpha customers... Only beneficial for cognitive tasks it would be safe is still unclear whether alpha-GPC improves cognition in individuals! L-Alpha-Glycerylphosphorylcholine have on natural medicines Comprehensive Database professional Version need to understand the... The Boston University research study showed that Alpha brain is Alpha GPC which... In Alpha brain TODAY < < < < < medications that affect blood clotting Take Adderall and vitamins, Vitamin. L-A glycerylphosphorylcholine with subsequent stroke risk after 10 Years not fit your specific health circumstances container, this nootropic be! Lesion area between Adderall and vitamins, including Vitamin D, Vitamin C, Vitamin C, Vitamin C Vitamin. Though Alpha brain with Adderall ; 14 ( 16 ):3349. doi:.. A variety of side effects gatti G, et al 14 ( 16 ):3349.:...
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